LFA-1 antagonist
LFA-1 integrin antagonist
- ↓ T-cell trafficking and inflammation
- ↓ ocular-surface inflammation → ↓ dry-eye signs and symptoms (ophthalmic)
- Blocks T-cell adhesion at the ocular surface — dry eye
Drugs with this mechanism (1)
- Lifitegrast — LFA-1 antagonist for dry eye; blocks T-cell costimulation at the ocular surface.
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