Kappa-opioid partial agonist
Kappa-opioid receptor partial agonist
- Mixed effects with a ceiling
- Direction depends on endogenous opioid tone
- Kappa activation → analgesia, dysphoria, sedation, diuresis
- Partial kappa activity contributes to mixed opioid profiles
Drugs with this mechanism (1)
- Nalmefene — Long-acting intranasal opioid antagonist for overdose reversal.
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