Kainate agonist
Kainate glutamate receptor agonist
- Slower excitatory currents than AMPA
- Modulates synaptic activity
- ↑ spinal pain signaling
- Overactivation → hippocampal excitotoxicity, seizures, amnesia
- Glutamate
- Produce smaller, slower excitatory currents that fine-tune synaptic activity
- Key role in spinal pain
Drugs with this mechanism (3)
- Domoic acid — Kainate-receptor agonist shellfish toxin causing amnesic poisoning.
- Glutamate — The primary excitatory neurotransmitter of the CNS.
- Kainate — Glutamate agonist that names the kainate receptor; an excitotoxin.
All mechanisms · Open Kainate agonist in the interactive console ↗