Integrase inhibitor
HIV integrase strand transfer inhibitor
- Blocks HIV integrase → viral DNA cannot insert into the host genome
- Rapid viral-load decline
- The “-tegravir” class
- Weight gain is a recognized effect
- Blocks integration of viral DNA into the host genome
- Well tolerated; weight gain with newer agents
Drugs with this mechanism (5)
- Bictegravir — HIV integrase inhibitor, a component of Biktarvy.
- Cabotegravir — Integrase inhibitor available as long-acting injectable treatment and PrEP.
- Dolutegravir — HIV integrase inhibitor with a high barrier to resistance.
- Elvitegravir — Integrase inhibitor that always needs a booster - cobicistat or ritonavir.
- Raltegravir — The first HIV integrase inhibitor.
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