NS3/4A protease inhibitor
Hepatitis C NS3/4A protease inhibitor
- Polyprotein cannot be cleaved
- A backbone of curative direct-acting antiviral regimens
- The “-previr” class
- Combined with agents of other classes to prevent resistance
- Blocks hepatitis C polyprotein cleavage
- Part of curative combination regimens
Drugs with this mechanism (4)
- Glecaprevir — Hepatitis C NS3/4A protease inhibitor.
- Grazoprevir — Hepatitis C NS3/4A protease inhibitor coformulated with elbasvir; avoid in decompensated liver disease.
- Paritaprevir — Hepatitis C NS3/4A protease inhibitor.
- Simeprevir — Older hepatitis C NS3/4A protease inhibitor; photosensitivity, rash, and substantial interaction burden.
All mechanisms · Open NS3/4A protease inhibitor in the interactive console ↗