H1 agonist
H1 histamine receptor agonist
- Acute allergic response (wheal, flare, itch)
- If BBB-crossing: wakefulness
- Vasodilation → flushing, headache, ↓ blood pressure
- Wakefulness and acute allergic response
Drugs with this mechanism (2)
- Betahistine — Histamine analog for Meniere vertigo (not US-approved).
- Histamine — Endogenous amine mediating arousal, allergy, and gastric acid.
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