GPER partial agonist
G protein-coupled estrogen receptor (GPER) partial agonist
- Fast, non-genomic estrogen signaling
- Distinct from the slow nuclear ERα/ERβ transcriptional actions
- Partial activation of membrane GPER — fast, non-genomic estrogen signaling
Drugs with this mechanism (1)
- Tamoxifen — The classic breast-cancer SERM; a prodrug activated by CYP2D6.
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