Glutamate-gated Cl channel agonist
Invertebrate glutamate-gated chloride channel agonist
- Hyperpolarization → parasite paralysis
- Kills nematodes and arthropods
- Mammals lack the channel
- Opens invertebrate chloride channels — parasite paralysis
- Mammals are spared: these channels are absent and the blood-brain barrier excludes it
Drugs with this mechanism (1)
- Ivermectin — Antiparasitic opening invertebrate glutamate-gated chloride channels.
All mechanisms · Open Glutamate-gated Cl channel agonist in the interactive console ↗