GH receptor antagonist
Growth hormone receptor antagonist
- ↓ IGF-1 production
- Controls acromegaly regardless of tumor somatostatin receptors
- GH levels RISE on treatment — follow IGF-1, not GH
- Blocks growth hormone signaling
- Lowers IGF-1 while growth hormone levels rise, since the hormone is not cleared
Drugs with this mechanism (1)
- Pegvisomant — Growth hormone RECEPTOR antagonist: IGF-1 falls while measured GH rises.
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