G-CSF agonist
G-CSF receptor agonist
- Neutrophil production accelerates → shortens chemotherapy neutropenia
- Mobilizes hematopoietic stem cells into peripheral blood
- Marrow expansion → bone pain
- Rare splenic rupture
- Stimulates neutrophil production after chemotherapy
- Bone pain; rare splenic rupture
Drugs with this mechanism (2)
- Filgrastim — Recombinant G-CSF that shortens chemotherapy-induced neutropenia.
- Pegfilgrastim — Long-acting G-CSF agonist preventing febrile neutropenia after myelosuppressive chemotherapy.
All mechanisms · Open G-CSF receptor agonist in the interactive console ↗