GAT-1 inhibitor
GABA transporter 1 reuptake inhibitor
- Synaptic GABA persists
- ↑ inhibitory signaling → antiseizure effect
- Can provoke absence-type spike-wave events — the wrong seizure types worsen
- Inhibits GABA transporter 1 (GAT1)
- ➔ antiepileptic drug
- ➔ off-label for social anxiety disorder
- ➔ may alter color perception ◇ brighter blues/greens ◇ via GABA-C receptors in retina
Drugs with this mechanism (1)
- Tiagabine — GAT-1 inhibitor that raises synaptic GABA; adjunctive anticonvulsant with paradoxical seizure risk.
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