FXR agonist
Farnesoid X receptor agonist
- FXR = the bile-acid nuclear receptor
- ↓ bile-acid synthesis and altered transport → treats cholestatic liver disease
- Pruritus and LDL rise are mechanism-linked
- Bile acid receptor activation — primary biliary cholangitis
- Pruritus; hepatotoxicity in advanced cirrhosis
Drugs with this mechanism (1)
- Obeticholic acid — FXR agonist for primary biliary cholangitis; pruritus is dose-limiting.
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