FMN cofactor: Complex I
- Entry point of NADH electrons into the respiratory chain
- Derived from riboflavin (vitamin B2)
- Riboflavin → FMN, the electron-entry flavin of Complex I (NADH → ubiquinone)
- First stop of the respiratory chain; riboflavin deficiency shows up as energy-pathway failure
Drugs with this mechanism (1)
- FMN — Riboflavin-derived redox cofactor; accepts electrons in mitochondrial complex I and other flavoprotein reactions.
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