TPO inhibitor
Thyroid peroxidase inhibitor
- No iodination or coupling → ↓ hormone synthesis
- Treats hyperthyroidism
- Onset awaits depletion of stored hormone
- Agranulocytosis and hepatotoxicity are the class dangers
- Agranulocytosis and hepatotoxicity are the serious risks
Drugs with this mechanism (2)
- Methimazole — First-line thyroid peroxidase inhibitor for hyperthyroidism.
- Propylthiouracil — Antithyroid drug preferred in first-trimester pregnancy; hepatotoxic.
All mechanisms · Open Thyroid peroxidase (TPO) inhibitor in the interactive console ↗