Thymidylate synthase inhibitor
- Thymidine depletion → DNA replication fails
- Rapidly dividing tissues suffer first: mucositis, myelosuppression, diarrhea
- Blocks thymidine synthesis — impaired DNA replication
- Myelosuppression and mucositis, severe where pyrimidine catabolism is impaired
Drugs with this mechanism (1)
- Fluorouracil — Thymidylate synthase inhibitor; DPD deficiency makes it lethal.
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