SYK inhibitor
Spleen tyrosine kinase (SYK) inhibitor
- ↓ Fc-receptor signaling
- Macrophages stop destroying antibody-coated platelets → treats ITP
- Hypertension and diarrhea are the common mechanism-linked effects
- Blocks spleen tyrosine kinase (SYK) downstream of Fc receptors
- Macrophages stop destroying antibody-coated platelets → treats refractory ITP
- Hypertension and diarrhea are the common mechanism-linked effects
Drugs with this mechanism (1)
- Fostamatinib — Prodrug of the SYK inhibitor R406 for chronic immune thrombocytopenia; diarrhea, hypertension, and liver-enzyme elevations.
All mechanisms · Open SYK inhibitor in the interactive console ↗