MEK inhibitor
- MEK (mitogen-activated protein kinase kinase) lies downstream of RAF
- Suppresses MAPK-pathway tumors
- Pairs with BRAF inhibitors
- Ocular (serous retinopathy) and cardiac (↓ EF) monitoring are class standards
- Blocks MAPK signaling downstream of BRAF
Drugs with this mechanism (1)
- Trametinib — MEK inhibitor usually paired with a BRAF inhibitor to delay resistance.
All mechanisms · Open MEK inhibitor in the interactive console ↗