IMPDH inhibitor
Inosine monophosphate dehydrogenase inhibitor
- ↓ guanine nucleotide synthesis
- Lymphocytes depend on this de novo route → selective immunosuppression
- GI toxicity and teratogenicity are the practical limits
- GI upset and cytopenias; teratogenic
Drugs with this mechanism (1)
- Mycophenolate mofetil — IMPDH inhibitor that starves lymphocytes of guanosine; teratogenic.
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