CYP17A1 inhibitor
- ↓ androgen synthesis everywhere, including tumor and adrenals
- Deepens androgen deprivation in prostate cancer beyond castration
- ↓ cortisol → ACTH-driven mineralocorticoid excess
- A glucocorticoid is co-administered to curb the ACTH drive
- Blocks androgen synthesis in prostate cancer
Drugs with this mechanism (1)
- Abiraterone — CYP17 inhibitor blocking androgen synthesis for prostate cancer; given with prednisone.
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