Carbonic anhydrase inhibitor
- ↓ H⁺ and HCO₃⁻ generation
- Bicarbonate diuresis → metabolic acidosis, kidney stones, hypokalemia
- ↓ aqueous humor → ↓ intraocular pressure
- ↓ CSF production → ↓ intracranial pressure
- Metabolic acidosis → ↑ ventilation → ↓ altitude illness
- Paresthesias
- Altered taste (flat carbonated drinks)
- Reduces aqueous humor production — glaucoma
- Alkaline diuresis and metabolic acidosis
- Antiepileptic and altitude sickness prophylaxis
Drugs with this mechanism (9)
- Acetazolamide — Carbonic anhydrase inhibitor for glaucoma, altitude illness, and raised intracranial pressure.
- Brinzolamide — Topical ocular carbonic anhydrase inhibitor; dorzolamide with less stinging.
- Dichlorphenamide — Carbonic anhydrase inhibitor for periodic paralysis.
- Dorzolamide — Topical carbonic anhydrase inhibitor that lowers intraocular pressure in glaucoma.
- Methazolamide — Carbonic anhydrase inhibitor for glaucoma.
- Topiramate ER (sprinkle) — Sprinkle-capsule extended-release topiramate for epilepsy and migraine prevention.
- Topiramate — Weight-reducing anticonvulsant for seizures and migraine; cognitive slowing limits it.
- Topiramate ER — Extended-release topiramate for seizures; cognitive slowing, kidney stones and fetal oral clefts.
- Zonisamide — Broad anticonvulsant associated with weight loss.
All mechanisms · Open Carbonic anhydrase inhibitor in the interactive console ↗