Aromatase inhibitor
- No androgen-to-estrogen conversion
- Estrogen deprivation treats hormone-receptor-positive breast cancer in postmenopausal women
- Estrogen loss → bone loss and arthralgia
- Blocks peripheral estrogen synthesis — postmenopausal breast cancer
- Arthralgia and bone loss
- Ineffective in premenopausal women without ovarian suppression
Drugs with this mechanism (3)
- Anastrozole — Aromatase inhibitor for estrogen-receptor-positive breast cancer.
- Exemestane — Steroidal, irreversible aromatase inhibitor—unlike the reversible triazoles.
- Letrozole — Aromatase inhibitor for breast cancer; also induces ovulation.
All mechanisms · Open Aromatase inhibitor in the interactive console ↗