ACL inhibitor

ATP-citrate lyase inhibitor

ATP-citrate lyase inhibitor — mechanism peg (Ballicules) — ACL inhibitor — mechanism card

Acts upstream of HMG-CoA reductase in cholesterol synthesis
↓ LDL cholesterol

Blocks cholesterol synthesis upstream of HMG-CoA reductase
Raises uric acid

Drugs with this mechanism (1)

Bempedoic acid — Liver-activated ATP-citrate lyase inhibitor; an oral LDL-lowering option in statin intolerance.

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