AADC inhibitor
Aromatic L-amino acid decarboxylase inhibitor
- Levodopa is not converted to dopamine outside the brain
- More levodopa reaches the CNS
- Peripheral dopamine nausea falls
- Blocks peripheral levodopa decarboxylation
- Allows more levodopa to reach the brain and reduces nausea
Drugs with this mechanism (1)
- Carbidopa — Peripheral AADC inhibitor given with levodopa to boost CNS delivery.
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