ENaC blocker
Epithelial sodium channel blocker
- ↓ Na⁺ reabsorption in the collecting duct
- Potassium-sparing diuresis; hyperkalemia risk
- Also the mechanism treating lithium-induced nephrogenic diabetes insipidus
- Potassium-sparing diuresis in the collecting duct
- Hyperkalemia risk
Drugs with this mechanism (3)
- Amiloride — ENaC-blocking potassium-sparing diuretic; treats Liddle syndrome and lithium-induced diabetes insipidus.
- Triamterene — Potassium-sparing diuretic (ENaC blocker), often with hydrochlorothiazide.
- Trimethoprim — Antifolate antibiotic; paired with sulfamethoxazole, raises potassium/creatinine.
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