DNA strand-break inducer
- Free-radical cleavage — acts on DNA itself rather than on an enzyme
- Kills dividing cells
- Potent in germ-cell tumors and lymphoma
- Pulmonary fibrosis and skin toxicity
Drugs with this mechanism (1)
- Bleomycin — DNA-strand-breaking chemotherapy with little myelosuppression but major pulmonary toxicity.
All mechanisms · Open DNA strand-break inducer in the interactive console ↗