DNA damage (nitroreduction)

DNA damage via nitroreduction

DNA damage via nitroreduction — mechanism peg (Ballicules) — DNA damage (nitroreduction) — mechanism card

Anaerobic nitroreduction generates DNA-damaging radicals inside the organism
Selective for anaerobes and microaerophilic protozoa — aerobes cannot activate it
The disulfiram-like alcohol reaction shares the same reactive chemistry

Nitroreduction generates DNA-damaging radicals in anaerobes

Drugs with this mechanism (1)

Metronidazole — Antibiotic/antiprotozoal for anaerobes; disulfiram-like reaction with alcohol.

All mechanisms · Open DNA damage (nitroreduction) in the interactive console ↗