DNA cross-linker
DNA cross-linking agent
- Blocks replication and transcription
- Broadly cytotoxic to dividing tumor cells
- Myelosuppression
- Platinum agents cross-link DNA strands
- Nephrotoxicity, ototoxicity, severe emesis
Drugs with this mechanism (1)
- Cisplatin — Platinum DNA-crosslinking chemotherapy; nephro-, oto-, and neurotoxic.
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