Delta-opioid agonist
Delta-opioid receptor agonist
- Modulates pain and mood without typical mu-opioid reward
- High activation can provoke seizures
- Pain modulation
- ➔ no known abuse liability
- Neuroplasticity signaling (preclinical)
- ➔ ↑ BDNF production
- Anti-inflammatory effects
- High-dose seizures (mechanism unclear)
Drugs with this mechanism (2)
- Beta-endorphin — Endogenous opioid peptide acting at mu and delta receptors.
- Enkephalin — Endogenous delta-preferring opioid peptides.
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