D3 agonist
D3 dopamine receptor agonist
- If BBB-crossing:
- ↑ limbic reward salience, motivation and psychomotor drive
- Excess activation → craving and impulse-control disorders
- ↑ reward salience (“wanting”), hedonic tone, psychomotor drive, and initiate
- ➔ ↓ anhedonia, ↑ motivation
- Excess D3 activation → craving, compulsive urges, impaired inhibition
Drugs with this mechanism (6)
- Apomorphine — D2/D3 agonist rescue for Parkinson OFF episodes; nausea and hypotension complicate use.
- Bromocriptine — Ergot dopamine agonist for prolactinomas and Parkinson disease; also used in diabetes.
- Dopamine — Dose-sensitive endogenous catecholamine agonist used IV for selected shock and hypotension.
- Pramipexole — Dopamine agonist for Parkinson and restless legs; impulse-control disorders.
- Ropinirole — D2/D3 agonist for Parkinson disease and restless legs; impulse-control risk.
- Rotigotine — Transdermal dopamine agonist for Parkinson and restless legs.
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