Cytochrome bc1 inhibitor
Mitochondrial cytochrome bc1 inhibitor
- Collapses protozoal and fungal mitochondrial electron transport
- ↓ pyrimidine synthesis in Plasmodium (DHODH depends on electron transport)
- Kills Plasmodium and Pneumocystis
- Blocks protozoal mitochondrial electron transport — atovaquone
Drugs with this mechanism (1)
- Atovaquone — Blocks protozoal mitochondrial electron transport; absorption needs fatty food.
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