CYP51 inhibitor
Lanosterol 14-alpha-demethylase (CYP51) inhibitor
- ↓ fungal ergosterol synthesis
- Defective fungal membranes → fungistatic-to-fungicidal effect
- Blocks fungal ergosterol synthesis — the azoles
- Potent CYP3A4 inhibition drives major interactions
- Hepatotoxicity and QT prolongation
Drugs with this mechanism (3)
- Fluconazole — Azole antifungal with good CNS penetration; a CYP2C9/3A inhibitor.
- Miconazole — Topical azole antifungal.
- Posaconazole — Broad triazole antifungal for prophylaxis in immunocompromised patients.
All mechanisms · Open CYP51 inhibitor in the interactive console ↗