CRF1 antagonist
Corticotropin-releasing factor 1 receptor antagonist
- ↓ pituitary ACTH drive → lets congenital adrenal hyperplasia be controlled with physiologic steroid doses
- Treats the axis, not the enzyme defect
- Reduces ACTH drive in congenital adrenal hyperplasia
- Allows lower glucocorticoid dosing
Drugs with this mechanism (1)
- Crinecerfont — CRF1 antagonist that reduces ACTH-driven androgen excess in congenital adrenal hyperplasia.
All mechanisms · Open CRF1 antagonist in the interactive console ↗