Coenzyme A: fatty-acid metabolism
- Coenzyme A thioesters activate fatty acids for synthesis and beta-oxidation
- Drug acyl-CoA trapping drains this pool
- Every fatty acid is handled as its CoA thioester — activation, transport handoff (to carnitine), beta-oxidation
Drugs with this mechanism (1)
- Coenzyme A — Pantothenate-derived carrier of acyl groups; central to fatty-acid metabolism and cellular energy production.
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