CCR5 antagonist
CCR5 co-receptor antagonist
- Prevents entry of CCR5-tropic HIV
- Requires a tropism assay first — useless against CXCR4-tropic virus
- Blocks HIV entry via the CCR5 co-receptor
- Works only against CCR5-tropic virus
- Hepatotoxicity
Drugs with this mechanism (1)
- Maraviroc — CCR5 entry inhibitor; requires a tropism assay before use.
All mechanisms · Open CCR5 antagonist in the interactive console ↗