CB1 partial agonist
Cannabinoid CB1 receptor partial agonist
- Source of the cannabis high
- Partial agonism caps the ceiling effect, unlike synthetic full agonists
- Dose-dependent anxiety, tachycardia and short-term memory impairment
- Hyperemesis with chronic heavy use
- ↑ appetite; antiemetic
- Source of the cannabis high
- Partial agonism caps the ceiling effect, unlike synthetic full agonists
- Dose-dependent anxiety, tachycardia and short-term memory impairment
- Hyperemesis with chronic heavy use
- ↑ appetite; antiemetic
Drugs with this mechanism (3)
- Anandamide — The first endocannabinoid identified; a partial CB1 agonist, degraded by FAAH.
- Dronabinol — Oral delta-9-THC for chemotherapy nausea and AIDS-related anorexia; a CB1/CB2 partial agonist.
- Tetrahydrocannabinol — The cannabinoid that makes cannabis psychoactive — CB1 partial agonist.
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