CB1 NAM
CB1 cannabinoid receptor negative allosteric modulator
- Dampens cannabinoid agonist responses without occupying the orthosteric site
- ↓ effects of CB1 agonists; may temper THC-type intoxication
- Possible antipsychotic effect
- Mechanism likely multifactorial
- ↑ endocannabinoid tone — anandamide rises by displacement from its carrier proteins, not by blocking human FAAH
- ↓ effects of CB1 agonists
- Possible antipsychotic effect
- ➔ mechanism likely multifactorial CB1
Drugs with this mechanism (1)
- Cannabidiol — Purified, nonintoxicating cannabinoid for severe developmental epilepsies.