BChE inhibitor
Butyrylcholinesterase (BChE) inhibitor
- ↓ acetylcholine degradation by plasma pseudocholinesterase (BChE)
- Additive with acetylcholinesterase inhibition
- BChE gains importance in advanced dementia as glial BChE rises
- Also called pseudocholinesterase (PChE) — a plasma enzyme, distinct from synaptic acetylcholinesterase
- ➔ BChE activity rises as Alzheimer disease progresses, so dual inhibition may matter more late
Drugs with this mechanism (1)
- Rivastigmine — Cholinesterase inhibitor available as a patch; also for Parkinson dementia.
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