BRAF inhibitor
BRAF kinase inhibitor
- Blocks mutant BRAF → shuts down MAPK (mitogen-activated protein kinase) growth signaling
- Suppresses BRAF-V600–driven melanoma and other tumors
- Paradoxical MAPK activation in BRAF-wild-type cells → cutaneous squamous cell carcinomas unless paired with a MEK inhibitor
- Targets BRAF V600E melanoma
Drugs with this mechanism (3)
- Dabrafenib — BRAF V600 inhibitor; paradoxically activates the pathway in BRAF-wild-type cells.
- Sorafenib — Multikinase inhibitor for selected liver, kidney, and thyroid cancers; hand-foot skin reaction, diarrhea, and hypertension are prominent.
- Vemurafenib — BRAF inhibitor for BRAF-V600E melanoma.
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