Biotin cofactor: propionyl-CoA carboxylase (PCC)
- Feeds odd-chain fatty acids and some amino acids into the TCA cycle
- Upstream partner of the B12-dependent methylmalonyl-CoA mutase step
- Odd-chain fats and several amino acids exit through propionyl-CoA → methylmalonyl-CoA; biotin carries the carboxyl
Drugs with this mechanism (1)
- Biocytin — Biotin bound to lysine; biotinidase recycles it into free biotin during protein breakdown.
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