Biotin cofactor: acetyl-CoA carboxylase (ACC)
- Commits acetyl-CoA to fatty-acid synthesis (malonyl-CoA)
- Malonyl-CoA also inhibits fatty-acid entry into mitochondria — a metabolic switch
- ACC's biotin arm builds malonyl-CoA — the committed step of fatty acid synthesis
Drugs with this mechanism (1)
- Biocytin — Biotin bound to lysine; biotinidase recycles it into free biotin during protein breakdown.
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