Beta-3 agonist
Beta-3 adrenergic receptor agonist
- Relaxes the bladder during filling → treats overactive bladder
- Alternative to antimuscarinics — no dry mouth or cognitive load
- Relaxation of detrusor muscle – treatment for overactive bladder
- Appetite suppression
- Adipose tissue beiging (improved metabolism)
- Negligible CNS effects
Drugs with this mechanism (3)
- Mirabegron — Beta-3 agonist for overactive bladder without antimuscarinic side effects.
- Nebivolol — Beta-1 blocker with beta-3 agonism and nitric-oxide-mediated vasodilation.
- Vibegron — Cleaner beta-3 agonist for overactive bladder; no CYP2D6 inhibition.
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