BCR-ABL/SRC inhibitor

BCR-ABL and SRC tyrosine kinase inhibitor

BCR-ABL and SRC tyrosine kinase inhibitor — mechanism peg (Ballicules) — BCR-ABL/SRC inhibitor — mechanism card

Suppresses resistant CML clones that escape ABL-only inhibitors
Pleural effusion is the signature class toxicity

Dual kinase inhibition in resistant CML

Drugs with this mechanism (1)

Dasatinib — BCR-ABL/Src inhibitor for CML; pleural effusions.

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