BCL-2 inhibitor
- Restores programmed cell death in cells addicted to anti-apoptotic BCL-2
- Deep responses in CLL and AML
- Apoptosis can be so rapid that tumor lysis syndrome mandates a dose ramp-up
- Restores apoptosis in cancers that survive by blocking it
- Rapid apoptosis of a large tumor burden causes tumor lysis syndrome
Drugs with this mechanism (1)
- Venetoclax — BH3 mimetic restoring apoptosis in CLL; ramp-up dosing to avoid tumor lysis.
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