Bacterial DNA damaging agent
- Intracellular reduction generates reactive intermediates that damage bacterial DNA
- Also damages ribosomal proteins and respiratory enzymes
- Bacterial nitroreductase provides selectivity
- Reduced intracellularly to reactive intermediates that damage bacterial DNA
- Also damages bacterial ribosomal proteins and respiratory enzymes
- Requires bacterial nitroreductase, which gives the selectivity
Drugs with this mechanism (1)
- Nitrofurantoin — Bladder-concentrated antibiotic for uncomplicated cystitis; useless for pyelonephritis.
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