B12 cofactor
Vitamin B12 cofactor
- Required cofactor for methionine synthase and methylmalonyl-CoA mutase
- Deficiency → megaloblastic anemia and neurologic dysfunction (subacute combined degeneration)
- Neurologic damage can proceed without anemia; folate can mask the blood picture but not the nerves
- Required for methionine synthase and methylmalonyl-CoA mutase
- Deficiency causes megaloblastic anemia and neuropathy
Drugs with this mechanism (1)
- Cyanocobalamin — Vitamin B12 supplement; converted to active cobalamin forms.
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