AMPA receptor negative allosteric modulator
- Dampens fast excitatory transmission
- Broad-spectrum antiseizure action
- Dose-related irritability/aggression and dizziness track the same dampening
- Principal antiepileptic mechanism of perampanel (Fycompa)
Drugs with this mechanism (6)
- Pentobarbital — Barbiturate used to induce coma in refractory status epilepticus.
- Perampanel — AMPA antagonist anticonvulsant; behavioral adverse effects.
- Phenobarbital — Oldest barbiturate anticonvulsant; sedating, enzyme-inducing, largely historical.
- Topiramate ER (sprinkle) — Sprinkle-capsule extended-release topiramate for epilepsy and migraine prevention.
- Topiramate — Weight-reducing anticonvulsant for seizures and migraine; cognitive slowing limits it.
- Topiramate ER — Extended-release topiramate for seizures; cognitive slowing, kidney stones and fetal oral clefts.
All mechanisms · Open AMPA receptor negative allosteric modulator in the interactive console ↗