Activin ligand trap
- Activin/TGF-beta (transforming growth factor beta) superfamily ligands intercepted before they reach their receptors
- Relieves the block on late-stage red-cell maturation
- Remodels pulmonary vasculature in PAH
- Telangiectasias, bleeding, thrombocytopenia
Drugs with this mechanism (1)
- Sotatercept — Activin ligand trap for pulmonary arterial hypertension; targets vascular remodeling, not just tone.
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