AChE reactivator
Acetylcholinesterase reactivator
- Reactivates organophosphate-inhibited acetylcholinesterase (AChE) by removing the phosphate from the enzyme’s active site
- Restores acetylcholine breakdown → reverses nicotinic weakness that muscarinic blockade cannot touch
- Must be given before enzyme “aging” makes the inhibition permanent — time is enzyme
- Reactivates acetylcholinesterase after organophosphate poisoning
- Must be given before enzyme aging becomes irreversible
Drugs with this mechanism (1)
- Pralidoxime — Reactivates cholinesterase; given with atropine for organophosphate poisoning.
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