Adenosine A2A agonist
Adenosine A2A receptor agonist
- Coronary vasodilation — exploited in pharmacologic stress testing
- Reduces platelet aggregation
- ↑ glutamate release
- Opposes D2 receptor signaling in striatum
- ➔ theoretical antipsychotic effect
- Coronary vessel dilation
- ↓ platelet aggregation
- Immunomodulatory effects
- Anti-inflammatory effects
- ➔ may be neuroprotective
Drugs with this mechanism (2)
- Adenosine — Endogenous nucleoside; IV bolus terminates SVT via transient AV block.
- Regadenoson — Selective A2A agonist for pharmacologic cardiac stress testing.
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