Adenosine A1 agonist
Adenosine A1 receptor agonist
- Gi-coupled → neuronal inhibition
- Promotes sleep pressure
- Slows sinus rate and AV (atrioventricular) conduction → terminates SVT
- Reduces glomerular filtration
Adenosine A1 agonist (1/2)
- Sleep promotion
- Cardiac effects
- ➔ negative chronotropy (↓ HR)
- ➔ negative dromotropy (↓ AV conduction)
- ➔ negative inotropy (↓ contractility)
- Adenosine approved for paroxysmal supraventricular tachycardia (PSVT)
- ➔ rapid IV bolus → transient AV-node block / brief asystole → terminates reentry
- Anticonvulsant effect
- Reduces glomerular filtration rate (GFR)
Adenosine A1 agonist (2/2)
- Inhibits lipolysis
- Antinociceptive effects
Drugs with this mechanism (1)
- Adenosine — Endogenous nucleoside; IV bolus terminates SVT via transient AV block.
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